FASDP, FASCP, FCAP · Dermatopathology · Metabolic Medicine Optimization / Obesity MedicineUNINFLAMED

I turn complex medical science into clear, honest answers, so you understand your body and make choices with confidence.

Evidence-Based Longevity • Metabolic Health • Emerging TherapiesYour Health Compass • Actionable Insights
Dr. Amin Hedayat, MD, FASDP, dermatopathologist
Board-Certified
Dermatopathology,
Anatomic & Clinical Pathology
Fellowship
Memorial Sloan Kettering,
Weill Cornell & UC San Francisco
Residency
Dartmouth
01 / Who I am

A pathologist
who explains medicine.

Dr. Amin Hedayat is triple board-certified in dermatopathology, anatomic pathology, and clinical pathology. He serves as a Medical School Assistant Clinical Professor, and practices dermatopathology and obesity medicine as part of his private practice.

He completed his dermatopathology fellowship at Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, where he was mentored by internationally renowned dermatopathologists and dermatologists. He completed his residency at Dartmouth.

Dr. Hedayat has authored numerous peer-reviewed publications and book chapters on advanced molecular testing in melanoma, melanocytic tumors, and cutaneous lymphoma. He has presented at national and international scientific meetings, and he is passionate about combating skin cancer through clinical practice, education, and research.

He completed education in obesity medicine and will sit for the American Board of Obesity Medicine diplomate exam in 2026.

Take what the evidence shows, cut the hype, and put it in plain language.

02 / Focus areas

Where I spend my attention.

GLP-1s, Peptides & Longevity

What semaglutide, tirzepatide, and the newer peptides actually do, what the trials show, and where the longevity evidence stands.

Obesity Medicine

Obesity is a disease, not a willpower problem. Hormones, genetics, and metabolism set body weight, and they fight hard to defend it. I treat it like any chronic condition: medication when the evidence supports it, nutrition that fits real life, and follow-up that lasts.

Dermatopathology

A biopsy lands on my desk, and the tissue tells a story. My job is to read it. Under the microscope, I look at skin one cell at a time and name what is wrong. I catch melanoma hiding among ordinary moles, along with basal and squamous cell carcinoma. I sort out lymphomas that start in the skin, the rashes of lupus and psoriasis, infections, and blistering diseases. One slide can separate a harmless mole from a melanoma that needs treatment now.

Melanoma & Skin Cancer

Chairman of the board of the American Melanoma Institute, with published work on molecular testing in melanoma and cutaneous lymphoma.

03 / On YouTube

Evidence, explained.

I break down the GLP-1 medications, the emerging therapies, and the metabolic science underneath them. Every claim carries its citation.

I'm a Pathologist. Celebrity Peptide Trends Are Sending People To ER.
Does Sunscreen Cause Cancer or Prevent Cancer?
Next Ozempic? Retatrutide's Unknown Skin Effect (Pathologist Explains)
Foundayo: New "Ozempic in a Pill". Here's the Catch.
The Protein Number Everyone Gets Wrong. Especially If On GLP1 Medications.
Perimenopause - If You Have Belly Fat After 40, Watch This.
I'm a Pathologist. Ozempic & Mounjaro Aren't Actually Weight Loss Drugs.
Ozempic, Mounjaro, Retatrutide: The Disease Your Labs Miss (Pathologist Explains)
I'm a Pathologist: The Biological Cost of Foundayo "Ozempic Pill" (The Metabolism Protocol)
The Neuroscience of Anhedonia, Belly Fat and Dopamine Blockage (Ep 3)
I'm a Pathologist. Retatrutide is NOT Ozempic. It's Biological Overdrive.
The Biology of Trauma & Weight Gain: Ozempic & Mounjaro Can't Fix This (Ep. 2)
Dopamine Hijack Won't Let You Lose Weight, Even On Ozempic And Mounjaro - Ep. 1
Ozempic & Mounjaro: Same Shot. Opposite Results.
If You Feel Numb Right Now, Watch This
The Carnivore Diet: Will It Save You or Kill You? (Forensic Analysis)
Pathologist: Coffee Is Not Energy. It's A Loan.
I'm a Pathologist: How To Boost GLP-1 Naturally (No Injections)
How To Stop The Rebound With Ozempic & Mounjaro

Latest Uploads

04 / Publications

Peer-reviewed work.

Books & Book Chapters

  1. Hedayat AA, Yan S, Tsongalis GJ. Molecular pathology and testing in melanocytic tumors. In: Coleman WB, Tsongalis GJ, eds. Diagnostic Molecular Pathology. 1st ed. Philadelphia, PA; 2017.
  2. Hedayat AA. Laboratory Medicine for Medical Students. 1st ed. Self Published; 2014.

Journal Articles

  1. Abbas H, Samlowski W, Hedayat AA. Durable remission of metastatic myxoid liposarcoma following the cautious addition of pembrolizumab to ongoing pazopanib treatment: a case report. Rare Tumors. 2026;18.
  2. Lee C, Hedayat AA, Greenberg HL. Cystic presentation of high-grade ductal carcinoma in situ in an inframammary accessory nipple. Cutis. 2023;112(2):E9-E11.
  3. Shawa H, Hedayat AA, Cotter D. Atypical presentation of pediatric antiphospholipid syndrome. JAAD Case Rep. 2021;16:50-52.
  4. Samlowski W, Chang M, Meoz R, Hedayat AA. Complete response of metastatic cervical adenocarcinoma treated with chemoradiotherapy followed by pembrolizumab: a case report. J Case Rep Images Oncol. 2021;7:100078Z10WS2021.
  5. Hedayat AA, Busam KJ, Lefferts JA, Linos K. BAP1-deficient tumor/nevus with germline aberration: a potential confounding factor in assessing melanocytic neoplasms with SNP array. J Cutan Pathol. 2019;46(9):672-677.
  6. Magro CM, Ruan J, Grossman M, Hedayat AA. Monoclonal plasma cell infiltrates in the setting of cutaneous follicular helper T-cell lymphoproliferative disorders. Ann Diagn Pathol. 2019;40:94-104.
  7. Magro CM, Schwartz Z, Saab A, Hedayat AA. Enhanced cutaneous ROCK2 expression as a marker of Rho kinase pathway activation in autoimmune disease and Kohlmeier-Degos disease. Ann Diagn Pathol. 2020;44:151414.
  8. Georgesen C, Hedayat AA, Hollmann TJ, Marchetti MA, Busam KJ, Rossi AM, Seo SK, Markova A. Gram-negative cutaneous infections with unique filamentous forms. J Cutan Pathol. 2019;46(6):459-462.
  9. Queen D, Hedayat AA, Magro C, Geskin LJ. An unusual cause of bilateral orbital swelling: IgG4-related orbital disease arising in a patient with ulcerative colitis. JAAD Case Rep. 2019;5(7):634-638.
  10. Magro CM, Solomon G, Hedayat AA. Angiodestructive type E lymphomatoid papulosis in the setting of pregnancy. The Dermatologist. 2018.
  11. Hedayat AA, Carter JB, Lansigan F, LeBlanc RE. Epidermotropic presentation by splenic B-cell lymphoma: the importance of clinical-pathologic correlation. J Cutan Pathol. 2018.
  12. Hedayat AA, Linos K, Jung HS, Tafe LJ, Yan S, LeBlanc RE, Lefferts JA. Evaluating melanocytic lesions with single nucleotide polymorphism (SNP) chromosomal microarray. Exp Mol Pathol. 2017;103(3):279-287. ASDP Award
  13. Hoyt BS, Hedayat AA, LeBlanc RE, Glass JS. Painful violaceous nodule with peripheral hyperpigmentation. Cutis. 2018;101(4):E6-E8.
  14. Hedayat AA, Collins LK, Wimmer DB, Guill MA, Seidel GD. A painful firm plaque on the midback of a 53-year-old female. Am J Dermatopathol. 2017.
  15. Hedayat AA, Peterson JD, Tse JY, Eifert CL, Gallagher TL, Deharvengt SJ, de Abreu FB, Tsongalis GJ. Assessing the clinical utility of expanded versus small targeted solid tumor NGS panels. Lab Invest. 2017;97:529A-530A.
  16. Hedayat AA, Suriawinata A, Lisovsky M, Longnecker DS. Association of IgG4 response and autoimmune pancreatitis with intraductal papillary-mucinous neoplasms. Pancreatology. 2017.
  17. Hedayat AA, Collins LK, Wimmer DB, Guill MA, Seidel GD. Fluoroscopy-induced chronic radiation dermatitis. Am J Dermatopathol. 2017.
  18. Hedayat AA, Linos K, Angeles C, Tsongalis GJ, Lefferts JA. Analysis of copy number variation in melanoma versus benign lesions using chromosomal microarray. J Cutan Pathol. 2016;43(1):e4-e5.
  19. Hedayat AA, Pettus JR, Marotti JD, Holubar SD, Lisovsky M. Proliferative lesion of anogenital mammary-like glands in the setting of Cowden syndrome: case report and review of the literature. J Cutan Pathol. 2016.
  20. Olson NJ, Robert D, Hedayat AA, Liu X, Ornstein DL. Fatal hemorrhage due to a spontaneous factor V inhibitor with lupus anticoagulant properties. Blood Coagul Fibrinolysis. 2016.
  21. Wimmer D, Hedayat AA, Li Z, Bagley E, Ernstoff M, Barton D, Yan S. Prognostic significance of rare intraparenchymal immunohistochemical positive cells in sentinel lymph nodes from melanoma patients. Lab Invest. 2015;95:127A-128A.
  22. Hedayat AA, Bortolato M, Piomelli D. Addiction evaluation of endocannabinoid deactivating inhibitors. Undergraduate Research Opportunity Program Journal. 7th ed. 2005.
  23. Hedayat AA, Piomelli D. Rewarding effects of endocannabinoid deactivation inhibitors. UC Irvine Excellence in Research Journal of Undergraduate Research in the Biological Sciences. 2005;35.
  24. Hedayat AA, Essad KM, Kanter JH, Memoli VA, Lukovitz TG. Post-partum cerebral vascular accident caused by mycotic embolism. J Stroke Cerebrovasc Dis. 2016.